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Also noteworthy earlier this month was the publication of a Phase 2 randomized trial in 272 participants without diabetes of orforglipron, an oral GLP-1 agonist, which achieved a 14.7% weight loss (placebo-adjusted 12.3%) at the highest dose With that brief review of the latest trials and drugs, let’s turn to clinical outcomes, for which most are taking us back to single agonist—GLP-1—drugs

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To address potential confounding factors, investigators also performed a propensity-matched analysis pairing GLP-1 users and non-users based on age, race, ethnicity, body mass index, breast density, and diabetes status